Titre
Microautophagy in the yeast Saccharomyces cerevisiae.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Methods in Molecular Biology
Auteur(s)
Uttenweiler, A.
Auteure/Auteur
Mayer, A.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1064-3745
Statut éditorial
Publié
Date de publication
2008
Volume
445
Première page
245
Dernière page/numéro d’article
259
Langue
anglais
Résumé
Microautophagy involves direct invagination and fission of the vacuolar/lysosomal membrane under nutrient limitation. In Saccharomyces cerevisiae microautophagic uptake of soluble cytosolic proteins occurs via an autophagic tube, a highly specialized vacuolar membrane invagination. At the tip of an autophagic tube vesicles (autophagic bodies) pinch off into thevacuolar lumen for degradation. Formation of autophagic tubes is topologically equivalent to other budding processes directed away from the cytosolic environment, e.g., the invagination of multivesicular endosomes, retroviral budding, piecemeal microautophagy of the nucleus and micropexophagy. This clearly distinguishes microautophagy from other membrane fission events following budding toward the cytosol. Such processes are implicated in transport between organelles like the plasma membrane, the endoplasmic reticulum (ER), and the Golgi. Over many years microautophagy only could be characterized microscopically. Recent studies provided the possibility to study the process in vitro and have identified the first molecules that are involved in microautophagy.
PID Serval
serval:BIB_1D998CA59A5B
PMID
Date de création
2009-01-29T21:13:36.920Z
Date de création dans IRIS
2025-05-20T19:38:21Z