Titre
Peri-implant bone remodeling after total hip replacement combined with systemic alendronate treatment: a finite element analysis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Peter, B.
Auteure/Auteur
Ramaniraka, N.
Auteure/Auteur
Rakotomanana, L.R.
Auteure/Auteur
Zambelli, P.Y.
Auteure/Auteur
Pioletti, D.P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1025-5842
Statut éditorial
Publié
Date de publication
2004-04
Volume
7
Numéro
2
Première page
73
Dernière page/numéro d’article
78
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Comparative Study ; Evaluation Studies ; Journal Article ; Validation Studies
Publication Status: ppublish
Publication Status: ppublish
Résumé
In order to decrease the peri-implant bone loss during the life-time of the implant, oral use of anti-osteoporosis drugs (like bisphosphonates) has been suggested. In this study, bone remodeling parameters identified from clinical trials of alendronate were used to simulate the effect of those drugs used after total hip arthroplasty on the peri-implant bone density. Results of the simulation show that the oral administrated drugs increase bone density around the implant and decreases, at the same time, the micromovements between the implant and the surrounding bone tissue. Incorporation of drug effect in numerical studies of bone remodeling is a promising tool especially to predetermine safe bisphosphonate doses that could be used with orthopedic implants.
Sujets
PID Serval
serval:BIB_4CA0D8349F40
PMID
Date de création
2008-01-28T11:29:12.605Z
Date de création dans IRIS
2025-05-20T19:49:18Z