Titre
Swiss expert opinion: current approaches in faecal microbiota transplantation in daily practice.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Rossier, L.
Auteure/Auteur
Matter, C.
Auteure/Auteur
Burri, E.
Auteure/Auteur
Galperine, T.
Auteure/Auteur
Hrúz, P.
Auteure/Auteur
Juillerat, P.
Auteure/Auteur
Schoepfer, A.
Auteure/Auteur
Vavricka, S.R.
Auteure/Auteur
Zahnd, N.
Auteure/Auteur
Décosterd, N.
Auteure/Auteur
Seibold, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1424-3997
Statut éditorial
Publié
Date de publication
2023-08-25
Volume
153
Première page
40100
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review ; Systematic Review
Publication Status: epublish
Publication Status: epublish
Résumé
Faecal microbiota transplantation (FMT) is an established therapy for recurrent C. difficile infection, and recent studies have reported encouraging results of FMT in patients with ulcerative colitis. Few international consensus guidelines exist for this therapy, and thus FMT policies and practices differ among European countries. As of 2019, stool transplants are considered a non-standardised medicinal product in Switzerland, and a standardised production process requires authorisation by the Swiss Agency for Therapeutic Products. This authorisation leads to prolonged administrative procedures and increasing costs, which reduces treatment accessibility. In particular, patients with ulcerative colitis in Switzerland can only benefit from FMT off-label, even though it is a valid therapeutic option. Therefore, this study summarised the available data on FMT and established a framework for the standardised use of FMT.
A panel of Swiss gastroenterologists with a special interest in inflammatory bowel disease was established to identify the current key issues of FMT. After a comprehensive review of the literature, statements were formulated about FMT indications, donor screening, stool transplant preparation and administration, and safety aspects. The panel then voted on the statements following the Delphi process; the statements were reformulated and revoted until a consensus was reached. The manuscript was then reviewed by an infectiologist (the head of Lausanne's FMT centre).
The established statements are summarised in the supplementary tables in the appendix to this paper. The working group hopes these will help standardise FMT practice in Switzerland and contribute to making faecal microbiota transplantation a safe and accessible treatment for patients with recurrent C. difficile infections and selected patients with ulcerative colitis, as well as other indications in the future.
A panel of Swiss gastroenterologists with a special interest in inflammatory bowel disease was established to identify the current key issues of FMT. After a comprehensive review of the literature, statements were formulated about FMT indications, donor screening, stool transplant preparation and administration, and safety aspects. The panel then voted on the statements following the Delphi process; the statements were reformulated and revoted until a consensus was reached. The manuscript was then reviewed by an infectiologist (the head of Lausanne's FMT centre).
The established statements are summarised in the supplementary tables in the appendix to this paper. The working group hopes these will help standardise FMT practice in Switzerland and contribute to making faecal microbiota transplantation a safe and accessible treatment for patients with recurrent C. difficile infections and selected patients with ulcerative colitis, as well as other indications in the future.
PID Serval
serval:BIB_0CA45BC676CD
PMID
Open Access
Oui
Date de création
2023-10-06T13:30:58.040Z
Date de création dans IRIS
2025-05-20T20:03:26Z
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Nom
37769622.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
814.37 KB
Format
Adobe PDF
PID Serval
serval:BIB_0CA45BC676CD.P001
URN
urn:nbn:ch:serval-BIB_0CA45BC676CD8
Somme de contrôle
(MD5):25970fbab6e5dec9e25b3dbb5043a615