Titre
Non-functioning pituitary carcinoma
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Imboden, P. N.
Auteure/Auteur
Borruat, F. X.
Auteure/Auteur
De Tribolet, N.
Auteure/Auteur
Meagher-Villemure, K.
Auteure/Auteur
Pica, A.
Auteure/Auteur
Gomez, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1386-341X
Statut éditorial
Publié
Date de publication
2004
Volume
7
Numéro
3
Première page
149
Dernière page/numéro d’article
56
Notes
Case Reports
Journal Article
Journal Article
Résumé
Null-cell carcinomas of the pituitary are extremely rare. We describe a 41-year-old woman with a large adenohypophyseal neoplasm presenting as a primary nonfunctioning tumor without pituitary insufficiency. Signs of mass effect with progressive unilateral ocular motility disorders and anterior pituitary failure developed rapidly. Histopathological examination of the trans-sphenoidally removed tumor showed a primary pituitary null cell tumor with high mitotic index. Pituitary carcinoma was suspected because of rapid relapse of ocular motility disorders and of intra-sellar tumor growth after surgery. Radiotherapy of the sellar and parasellar area with a total dose of 59.4 Gy was performed, achieving marked tumor reduction and a significant improvement of ocular motility disorders. However, 6.5 months after presentation the patient rapidly declined and died of carcinomatous meningitis.Less than 100 pituitary carcinomas have been published so far, most of them as single-case reports, and endocrine, immunohistochemical, and ultrastructural data have not been described in the majority of cases. At presentation, there are no specific symptoms that allow to distinguish benign from malignant tumor. Prognosis is poor, since no curative treatment has been established, but aggressive surgery and radiotherapy has been recommended. Our case highlights the poor prognosis of nonfunctioning pituitary carcinomas.
Sujets
PID Serval
serval:BIB_3F4F0E039D02
PMID
Date de création
2008-01-28T11:37:56.143Z
Date de création dans IRIS
2025-05-20T20:45:14Z