Titre
Anti-Nogo-A Antibody Treatment Promotes Recovery of Manual Dexterity after Unilateral Cervical Lesion in Adult Primates--re-examination and Extension of Behavioral Data.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Freund, Patrick
Auteure/Auteur
Schmidlin, Eric
Auteure/Auteur
Wannier, Thierry
Auteure/Auteur
Bloch, Jocelyne
Auteure/Auteur
Mir, Anis
Auteure/Auteur
Schwab Martin, E.
Auteure/Auteur
Rouiller Eric, M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1460-9568
Statut éditorial
Publié
Date de publication
2009
Volume
29
Numéro
5
Première page
983
Dernière page/numéro d’article
996
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
In rodents and nonhuman primates subjected to spinal cord lesion, neutralizing the neurite growth inhibitor Nogo-A has been shown to promote regenerative axonal sprouting and functional recovery. The goal of the present report was to re-examine the data on the recovery of the primate manual dexterity using refined behavioral analyses and further statistical assessments, representing secondary outcome measures from the same manual dexterity test. Thirteen adult monkeys were studied; seven received an anti-Nogo-A antibody whereas a control antibody was infused into the other monkeys. Monkeys were trained to perform the modified Brinkman board task requiring opposition of index finger and thumb to grasp food pellets placed in vertically and horizontally oriented slots. Two parameters were quantified before and following spinal cord injury: (i) the standard 'score' as defined by the number of pellets retrieved within 30 s from the two types of slots; (ii) the newly introduced 'contact time' as defined by the duration of digit contact with the food pellet before successful retrieval. After lesion the hand was severely impaired in all monkeys; this was followed by progressive functional recovery. Remarkably, anti-Nogo-A antibody-treated monkeys recovered faster and significantly better than control antibody-treated monkeys, considering both the score for vertical and horizontal slots (Mann-Whitney test: P = 0.05 and 0.035, respectively) and the contact time (P = 0.008 and 0.005, respectively). Detailed analysis of the lesions excluded the possibility that this conclusion may have been caused by differences in lesion properties between the two groups of monkeys.
Sujets
PID Serval
serval:BIB_5F30A2BC9176
PMID
Open Access
Oui
Date de création
2010-02-09T10:25:08.155Z
Date de création dans IRIS
2025-05-20T20:56:12Z
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Nom
19291225_BIB_5F30A2BC9176.pdf
Version du manuscrit
published
Taille
1.11 MB
Format
Adobe PDF
PID Serval
serval:BIB_5F30A2BC9176.P001
URN
urn:nbn:ch:serval-BIB_5F30A2BC91764
Somme de contrôle
(MD5):78da6993fe41d0a930f76a1e5b889ea7