Titre
Sex-related differences in endothelial function and blood viscosity in the elderly population.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Raberin, A.
Auteure/Auteur
Martin, C.
Auteure/Auteur
Celle, S.
Auteure/Auteur
Hupin, D.
Auteure/Auteur
Roche, F.
Auteure/Auteur
Barthelemy, J.C.
Auteure/Auteur
Connes, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1664-042X
Statut éditorial
Publié
Date de publication
2023
Volume
14
Première page
1151088
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Elderly represents a growing population and cardiovascular diseases (CVD) is one of the leading causes of mortality in this population. Sex differences are involved in CVD with middle-aged males being at higher risk than females. After menopause, females are no longer protected by hormones and the role of sex on cardiovascular parameters involved in CVD, such as endothelial function and blood viscosity, is still unclear. The purpose of this study was to investigate the effect of sex on endothelial function, blood viscosity and CVD in elderly. Clinical investigation and blood analyses were performed on 182 (93 females and 89 males) elderly participants (mean age: 75.83 ± 1.22). Health status of participants were classified. Sex differences in endothelial function, blood viscosity, high density lipoprotein (HDL), hematocrit, and red blood cell (RBC) aggregation were assessed. CVD prevalence was higher in males (27.0%) than in females (5.4%) (p < 0.001). Females had higher vasoreactivity (p = 0.014) and HDL (p < 0.001) level than males. Blood viscosity was higher in males than in females at any shear rate (p < 0.001). Hematocrit was greater in males than in females (p < 0.001) while RBC aggregation did not differ between the two populations. To conclude, females have less CVD than age-matched males that might be due to their greater vascular function and lower blood viscosity.
PID Serval
serval:BIB_6A7F301EC756
PMID
Open Access
Oui
Date de création
2023-04-25T12:36:30.221Z
Date de création dans IRIS
2025-05-20T21:00:22Z
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Nom
12.Raberin et al. 2023 Front in physiol.pdf
Version du manuscrit
preprint
Licence
https://creativecommons.org/licenses/by/4.0
Taille
795.44 KB
Format
Adobe PDF
PID Serval
serval:BIB_6A7F301EC756.P001
Somme de contrôle
(MD5):687503ab106ae6f665733bbe2fde17b4