Titre
Laryngeal cancer in women: tobacco, alcohol, nutritional, and hormonal factors
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gallus, Silvano
Auteure/Auteur
Bosetti, Cristina
Auteure/Auteur
Franceschi, Silvia
Auteure/Auteur
Levi, Fabio
Auteure/Auteur
Negri, Eva
Auteure/Auteur
La Vecchia, Carlo
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1055-9965
Statut éditorial
Publié
Date de publication
2003
Volume
12
Numéro
6
Première page
514
Dernière page/numéro d’article
517
Notes
SAPHIRID:44897 --- Old url value: http://cebp.aacrjournals.org/cgi/content/full/12/6/514
Résumé
Laryngeal cancer is the neoplasm with the largest male to female sex ratio in most populations. Thus, inadequate data are available on women. We analyzed several risk factors in the combined dataset from two case-control studies conducted between 1986 and 2000 in northern Italy and Switzerland. Cases were 68 women under age 79 years, with incident, histologically confirmed cancer of the larynx. Controls were 340 women, admitted to the same network of hospitals as cases, for acute, nonmalignant conditions, unrelated to tobacco and alcohol consumption. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were estimated by logistic regression models, conditioned by age, study center and year of interview, and including terms for education, body mass index, tobacco, alcohol drinking, and nonalcohol energy intake. Laryngeal cancer was strongly associated with cigarette smoking (OR = 435.7, 95% CI: 38.2-4964.4 for smokers of >/=25 cigarettes/day) and alcohol drinking (OR = 4.3, 95% CI: 0.8-24.1 for >/=5 drinks/day). An inverse relation was found for vegetables (OR = 0.3, 95% CI: 0.1-0.9 for the highest level of consumption), fruit (OR = 0.5, 95% CI: 0.2-1.3), and olive oil (OR = 0.3, 95% CI: 0.1-0.9). Reproductive and hormonal factors were not consistently associated to laryngeal cancer risk. This investigation, based on a uniquely large number of laryngeal cancers in women, provides definite evidence that cigarette smoking is the prominent risk factor for laryngeal cancer in women, accounting for 78% of cases in this population. Alcohol and selected dietary aspects account for approximately 30% of cases, whereas menstrual and hormonal factors do not appear to have a consistent role in laryngeal carcinogenesis. [Authors]
PID Serval
serval:BIB_946779200A67
PMID
Date de création
2008-03-06T14:30:55.938Z
Date de création dans IRIS
2025-05-20T21:34:39Z