Titre
Molecular analysis of sleep.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Cold Spring Harbor Symposia on Quantitative Biology
Auteur(s)
Tafti, M.
Auteure/Auteur
Franken, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0091-7451[print], 0091-7451[linking]
Statut éditorial
Publié
Date de publication
2007
Volume
72
Première page
573
Dernière page/numéro d’article
578
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review Publication Status: ppublish
Résumé
Rest or sleep in all animal species constitutes a period of quiescence necessary for recovery from activity. Whether rest and activity observed in all organisms share a similar fundamental molecular basis with sleep and wakefulness in mammals has not yet been established. In addition and in contrast to the circadian system, strong evidence that sleep is regulated at the transcriptional level is lacking. Nevertheless, several studies indicate that single genesmay regulate some specific aspects of sleep. Efforts to better understand or confirm the role of known neurotransmission pathways in sleep-wake regulation using transgenic approaches resulted so far in only limited new insights. Recent gene expression profiling efforts in rats, mice, and fruit flies are promising and suggest that only a few gene categories are differentially regulated by behavioral state. How molecular analysis can help us to understand sleep is the focus of this chapter.
PID Serval
serval:BIB_96BD9564C929
PMID
Open Access
Oui
Date de création
2009-06-11T12:03:39.181Z
Date de création dans IRIS
2025-05-20T21:37:18Z