Titre
Thyro-entero-gastric autoimmunity: Pathophysiology and implications for patient management.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Lahner, E.
Auteure/Auteur
Conti, L.
Auteure/Auteur
Cicone, F.
Auteure/Auteur
Capriello, S.
Auteure/Auteur
Cazzato, M.
Auteure/Auteur
Centanni, M.
Auteure/Auteur
Annibale, B.
Auteure/Auteur
Virili, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1878-1594
Statut éditorial
Publié
Date de publication
2020-01
Volume
34
Numéro
1
Première page
101373
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
The association between autoimmune atrophic gastritis and thyroid disorders has been observed since the early 1960s and the expression "thyrogastric syndrome" was coined to indicate the presence of thyroid autoantibodies or autoimmune thyroid disease in patients with pernicious anemia, a late clinical stage of autoimmune atrophic gastritis. More recently, it was confirmed that autoimmune thyroid disorders, in particular Hashimoto's thyroiditis, may be frequently associated with other organ-specific, immune-mediated disorders, such as autoimmune atrophic gastritis or celiac disease. The association of Hashimoto's thyroiditis with autoimmune atrophic gastritis or celiac disease in adult patients is currently considered part of the polyglandular autoimmune syndromes which include several autoimmune disorders associated with an autoaggressive impairment of endocrine glands. From a clinical point of view, the thyro-entero-gastric autoimmunity may lead to potentially serious consequences like anemia, micronutrients deficiencies, and drugs malabsorption, as well as to an increased risk for malignancies. These alterations may frequently present in an underhand manner, with consequent diagnostic and treatment delays. Many aspects of the association between thyroid, gastric and intestinal autoimmune diseases still await clarification. The present review focuses on the embryological, genetic and pathophysiological aspects of thyro-entero-gastric autoimmunity. In particular, the current diagnostic criteria of autoimmune thyroid disease, autoimmune atrophic gastritis, and celiac disease are reviewed, along with the evidences for their association in poly-autoimmunity syndromes. The benefits of proactive screening of autoimmune thyroid disorders in patients with autoimmune gastritis or enteropathy and viceversa are also discussed.
PID Serval
serval:BIB_C17844FE9925
PMID
Date de création
2020-01-03T14:56:06.495Z
Date de création dans IRIS
2025-05-20T21:48:45Z