Titre
First Insights into Human Fingertip Regeneration by Echo-Doppler Imaging and Wound Microenvironment Assessment.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jafari, P.
Auteure/Auteur
Muller, C.
Auteure/Auteur
Grognuz, A.
Auteure/Auteur
Applegate, L.A.
Auteure/Auteur
Raffoul, W.
Auteure/Auteur
di Summa, P.G.
Co-dernière auteure/Co-dernier auteur
Durand, S.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1422-0067
Statut éditorial
Publié
Date de publication
2017-05-13
Volume
18
Numéro
5
Première page
0
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Fingertip response to trauma represents a fascinating example of tissue regeneration. Regeneration derives from proliferative mesenchymal cells (blastema) that subsequently differentiate into soft and skeletal tissues. Clinically, conservative treatment of the amputated fingertip under occlusive dressing can shift the response to tissue loss from a wound repair process towards regeneration. When analyzing by Immunoassay the wound exudate from occlusive dressings, the concentrations of brain-derived neurotrophic factor (BDNF) and leukemia inhibitory factor (LIF) were higher in fingertip exudates than in burn wounds (used as controls for wound repair versus regeneration). Vascular endothelial growth factor A (VEGF-A) and platelet-derived growth factor (PDGF) were highly expressed in both samples in comparable levels. In our study, pro-inflammatory cytokines were relatively higher expressed in regenerative fingertips than in the burn wound exudates while chemokines were present in lower levels. Functional, vascular and mechanical properties of the regenerated fingertips were analyzed three months after trauma and the data were compared to the corresponding fingertip on the collateral uninjured side. While sensory recovery and morphology (pulp thickness and texture) were similar to uninjured sides, mechanical parameters (elasticity, vascularization) were increased in the regenerated fingertips. Further studies should be done to clarify the importance of inflammatory cells, immunity and growth factors in determining the outcome of the regenerative process and its influence on the clinical outcome.
Sujets
PID Serval
serval:BIB_CB4046B499D3
PMID
Open Access
Oui
Date de création
2017-05-23T15:46:43.981Z
Date de création dans IRIS
2025-05-20T21:51:54Z
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Nom
ijms-18-01054.pdf
Version du manuscrit
published
Taille
6.26 MB
Format
Adobe PDF
PID Serval
serval:BIB_CB4046B499D3.P001
URN
urn:nbn:ch:serval-BIB_CB4046B499D31
Somme de contrôle
(MD5):cc7d466187fe016f9625cb0d1c81317f