Titre
PPARs: nuclear receptors for fatty acids, eicosanoids, and xenobiotics.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Advances in Experimental Medicine and Biology
Auteur(s)
Devchand, P.R.
Auteure/Auteur
Ijpenberg, A.
Auteure/Auteur
Devesvergne, B.
Auteure/Auteur
Wahli, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0065-2598[print], 0065-2598[linking]
Statut éditorial
Publié
Date de publication
1999
Volume
469
Première page
231
Dernière page/numéro d’article
236
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The peroxisome proliferator-activated receptors have enjoyed the spotlight for many reasons. These transcription factors are ligand-inducible nuclear receptors that modulate gene expression in response to a broad spectrum of compounds. The recognition that PPARs are indeed nuclear receptors for polyunsaturated fatty acids, some eicosanoids and also lipid-lowering and antidiabetic drugs, has opened many exciting avenues of research and drug discovery. Recent studies on the PPAR function have extended the role of these transcription factors beyond energy homeostasis to master gene in adipogenesis and also determinants in inflammation control. While rapid advances have been made, it is clear that we are far from a global understanding of the mechanisms and functions of PPARs.
Sujets
PID Serval
serval:BIB_921F2725A575
PMID
Date de création
2008-01-24T15:04:17.174Z
Date de création dans IRIS
2025-05-20T22:03:34Z