Titre
Effects of the long-acting somatostatin analogue SMS 201-995 in an infant with intractable diarrhea.
Type
étude de cas
Institution
Externe
Périodique
Helvetica Paediatrica Acta
Auteur(s)
Hunziker, U.A.
Auteure/Auteur
Superti-Furga, A.
Auteure/Auteur
Zachmann, M.
Auteure/Auteur
Del Pozo, E.
Auteure/Auteur
Shmerling, D.
Auteure/Auteur
Prader, A.
Auteure/Auteur
Liens vers les personnes
ISSN
0018-022X
Statut éditorial
Publié
Date de publication
1988
Volume
43
Numéro
1-2
Première page
103
Dernière page/numéro d’article
109
Langue
anglais
Notes
Publication types: Case Reports ; Journal ArticlePublication Status: ppublish
Résumé
The long-acting somatostatin analogue SMS 201-995 was administered to a six-month-old infant with intractable diarrhea after failure of conventional treatment. During eight weeks of treatment, the secretory component of the diarrhea was positively influenced with a reduction of daily stool weight and stool sodium concentration. Plasma levels of growth hormone were markedly, and levels of insulin, IGF I, gastrin, pancreatic polypeptide, VIP, and neurotensin moderately decreased. Linear growth was also inhibited. The patient unexpectedly died from fulminant colitis at a time, when the dosage had been reduced from 18 to 3.5 micrograms/kg/day. The relationship, if any, between therapy with SMS 201-995 and the colitis remained unclear. It is concluded that SMS 201-995 can be effective in reducing secretory diarrhea in infants. However, further studies are necessary to assess the safety of its administration in this age group.
PID Serval
serval:BIB_9FC83789DE66
PMID
Date de création
2011-03-14T15:14:10.461Z
Date de création dans IRIS
2025-05-20T22:11:41Z