Titre
Central line sepsis in intensive care units : overview and update
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Current Anaesthesia and Critical Care
Auteur(s)
Eggimann, P.
Auteure/Auteur
Pittet, D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0953-7112
Statut éditorial
Publié
Date de publication
1999
Volume
10
Numéro
1
Première page
14
Dernière page/numéro d’article
20
Langue
anglais
Résumé
Catheter-related infection remains a leading cause of nosocomial infections, particularly in intensive care units. It includes colonization of the device, skin exit-site infection and device- or catheter-related bloodstream infection. The latter represents the most frequent life-threatening associated complication of central venous catheter use and is associated with significant patient morbidity, mortality and extra hospital costs. The incidence of catheter-related bloodstream infection ranges from 2 to 14 episodes per 1000 catheter-days. On average, microbiologically-documented device-related bloodstream infections complicate from three to five per 100 central venous line uses, but they only represent the visible part of the iceberg and most clinical sepsis are nowadays considered to be catheter-related. We briefly review the pathophysiology of infection, highlighting the importance of the skin insertion site and of intravenous line hub as principal sources of colonization. Principles of therapy are reviewed. Several preventive approaches are also discussed, in particular the possible benefit of recently developed impregnated catheters. Finally, the potential positive impact of a multimodal global preventive strategy based on strict application of hygienic rules is presented.
PID Serval
serval:BIB_CC5F0F4149D3
Date de création
2009-10-06T16:05:18.839Z
Date de création dans IRIS
2025-05-20T22:19:28Z