Titre

Skin barrier immunology from early life to adulthood.

Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Trompette, A.
Auteure/Auteur
Ubags, N.D.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1935-3456
Statut éditorial
Publié
Date de publication
2023-04
Volume
16
Numéro
2
Première page
194
Dernière page/numéro d’article
207
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Our skin has a unique barrier function, which is imperative for the body's protection against external pathogens and environmental insults. Although interacting closely and sharing many similarities with key mucosal barrier sites, such as the gut and the lung, the skin also provides protection for internal tissues and organs and has a distinct lipid and chemical composition. Skin immunity develops over time and is influenced by a multiplicity of different factors, including lifestyle, genetics, and environmental exposures. Alterations in early life skin immune and structural development may have long-term consequences for skin health. In this review, we summarize the current knowledge on cutaneous barrier and immune development from early life to adulthood, with an overview of skin physiology and immune responses. We specifically highlight the influence of the skin microenvironment and other host intrinsic, host extrinsic (e.g. skin microbiome), and environmental factors on early life cutaneous immunity.
Sujets

Skin

Mucous Membrane

Microbiota

Lung

Environmental Exposur...

PID Serval
serval:BIB_681F0EC7058B
DOI
PMID
WOS
Permalien
Open Access
Oui
Date de création
2023-03-05T15:22:58.974Z
Date de création dans IRIS
2025-05-20T22:22:17Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

1-s2.0-S1933021923000132-main.pdf

Version du manuscrit

published

Licence

https://creativecommons.org/licenses/by/4.0

Taille

1.08 MB

Format

Adobe PDF

PID Serval

serval:BIB_681F0EC7058B.P001

URN

urn:nbn:ch:serval-BIB_681F0EC7058B1

Somme de contrôle

(MD5):b0c000c172b3ff5ba06e29ff14bbab8f