Titre
Copeptin as a diagnostic biomarker for sepsis-related deaths.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Palmiere, C.
Auteure/Auteur
Augsburger, M.
Auteure/Auteur
Liens vers les personnes
ISSN
1873-5169
Statut éditorial
Publié
Date de publication
2014
Volume
59
Première page
75
Dernière page/numéro d’article
78
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
Copeptin has been shown to increase in patients with sepsis, severe sepsis and septic shock. In the study herein described, copeptin was measured in a series of sepsis-related fatalities and control cases that underwent medico-legal investigations. No age-dependent differences in copeptin levels in either sepsis or control cases were observed. No correlation between copeptin concentrations and postmortem interval was identified in either group. Copeptin levels were significantly higher in sepsis cases. Moreover, copeptin concentrations in septic cases correlated with procalcitonin, C-reactive protein and interleukin 6 values. These preliminary findings seem to indicate that copeptin can be reliably measured in biological samples collected during postmortem investigations. These results also suggest that hemodynamic instability associated with sepsis and septic shock can be characterized by copeptin measurement also in the forensic casework.
PID Serval
serval:BIB_B810043173AA
PMID
Date de création
2014-10-02T16:27:34.086Z
Date de création dans IRIS
2025-05-20T22:41:40Z