Titre
A study on the interactions between heparan sulfate proteoglycans and Wnt proteins.
Type
article
Institution
Externe
Périodique
Auteur(s)
Fuerer, C.
Auteure/Auteur
Habib, S.J.
Auteure/Auteur
Nusse, R.
Auteure/Auteur
Liens vers les personnes
ISSN
1097-0177
Statut éditorial
Publié
Date de publication
2010-01
Volume
239
Numéro
1
Première page
184
Dernière page/numéro d’article
190
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The Wnt signaling pathway plays key roles in development and adult homeostasis. Wnt proteins are secreted, lipid-modified glycoproteins. They can form morphogen gradients that are regulated at the level of protein secretion, diffusion, and internalization. These gradients can only exist if the hydrophobic Wnt proteins are prevented from aggregating in the extracellular environment. Heparan sulfate proteoglycans (HSPGs) are necessary for proper activity of Wnt proteins and influence their distribution along the morphogenetic gradient. In this study, we show that HSPGs are able to maintain the solubility of Wnt proteins, thus stabilizing their signaling activity. Our results suggest that the role of HSPGs is not only to concentrate Wnt molecules at the cell surface but also to prevent them from aggregating in the extracellular environment.
PID Serval
serval:BIB_CB74DB55AAE5
PMID
URL éditeur
Date de création
2025-03-13T15:41:29.675Z
Date de création dans IRIS
2025-05-20T22:45:14Z