Titre
Impact of the C2/C6 ratio of high-molecular-weight hydroxyethyl starch on pharmacokinetics and blood coagulation in pigs.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Schramm, S.
Auteure/Auteur
Thyes, C.
Auteure/Auteur
Frascarolo, P.
Auteure/Auteur
Buclin, T.
Auteure/Auteur
Burki, M.
Auteure/Auteur
Fisch, A.
Auteure/Auteur
Burmeister, M.A.
Auteure/Auteur
Asmis, L.
Auteure/Auteur
Spahn, D.R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0003-3022
Statut éditorial
Publié
Date de publication
2007
Volume
107
Numéro
3
Première page
442
Dernière page/numéro d’article
451
Peer-reviewed
Oui
Langue
anglais
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
BACKGROUND: High-molecular-weight, low-substituted hydroxyethyl starch (HES) may not affect blood coagulation more than low-molecular-weight, low-substituted HES. The authors assessed in vivo the effect of a lowered C2/C6 ratio on pharmacokinetic characteristics and the impact on blood coagulation of high-molecular-weight, low-substituted HES. METHODS: A prospective, randomized, parallel study in 30 pigs compared HES 650/0.42/2.8 with HES 650/0.42/5.6. Before, during, and after infusion of 30 ml/kg body weight HES, blood samples were collected over 630 min to measure HES concentrations and plasmatic coagulation and to assess blood coagulation in whole blood by Thrombelastography (TEG; Haemoscope Corporation, Niles, IL). Pharmacokinetic parameters were estimated using a two-compartment model. RESULTS: The elimination constant was 0.009 +/- 0.001 min(-1) for HES 650/0.42/2.8 and 0.007 +/- 0.001 min(-1) for HES 650/0.42/5.6 (P < 0.001); the area under the plasma concentration-time curve was 1,374 +/- 340 min x g/l for HES 650/0.42/2.8 and 1,697 +/- 411 min x g/l for HES 650/0.42/5.6 (P = 0.026). The measured plasma HES concentrations were not different between HES 650/0.42/2.8 and HES 650/0.42/5.6. Both HES solutions equally affected blood coagulation: Thrombelastographic coagulation index decreased similarly at the end of infusion of HES 650/0.42/2.8 and at the end of infusion of HES 650/0.42/5.6 (P = 0.293). Also, activated partial thromboplastin and prothrombin times increased similarly for HES 650/0.42/2.8 and HES 650/0.42/5.6 (P = 0.831). CONCLUSION: Reducing the C2/C6 ratio in high-molecular, low-substituted HES solutions results in a slightly faster HES elimination. However, the blood coagulation compromising effect was unaffected.
PID Serval
serval:BIB_75938732CBB7
PMID
Open Access
Oui
Date de création
2008-01-25T09:45:42.577Z
Date de création dans IRIS
2025-05-20T22:56:42Z