Titre
Combining a Toggle Switch and a Repressilator within the AC-DC Circuit Generates Distinct Dynamical Behaviors.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Perez-Carrasco, R.
Auteure/Auteur
Barnes, C.P.
Auteure/Auteur
Schaerli, Y.
Auteure/Auteur
Isalan, M.
Auteure/Auteur
Briscoe, J.
Auteure/Auteur
Page, K.M.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2405-4712
Statut éditorial
Publié
Date de publication
2018-04-25
Volume
6
Numéro
4
Première page
521
Dernière page/numéro d’article
530.e3
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Although the structure of a genetically encoded regulatory circuit is an important determinant of its function, the relationship between circuit topology and the dynamical behaviors it can exhibit is not well understood. Here, we explore the range of behaviors available to the AC-DC circuit. This circuit consists of three genes connected as a combination of a toggle switch and a repressilator. Using dynamical systems theory, we show that the AC-DC circuit exhibits both oscillations and bistability within the same region of parameter space; this generates emergent behaviors not available to either the toggle switch or the repressilator alone. The AC-DC circuit can switch on oscillations via two distinct mechanisms, one of which induces coherence into ensembles of oscillators. In addition, we show that in the presence of noise, the AC-DC circuit can behave as an excitable system capable of spatial signal propagation or coherence resonance. Together, these results demonstrate how combinations of simple motifs can exhibit multiple complex behaviors.
PID Serval
serval:BIB_832AED933B6C
PMID
Open Access
Oui
Date de création
2018-03-29T17:00:49.968Z
Date de création dans IRIS
2025-05-20T23:04:11Z
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Nom
1-s2.0-S2405471218300619-main.pdf
Version du manuscrit
published
Taille
2.75 MB
Format
Adobe PDF
PID Serval
serval:BIB_832AED933B6C.P001
URN
urn:nbn:ch:serval-BIB_832AED933B6C5
Somme de contrôle
(MD5):272f931ad3f936866b0ba45065da0049