Titre
Involvement of calmodulin in the activation of store-operated Ca2+ entry in rat hepatocytes
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Cao, Y.
Auteure/Auteur
Chatton, J. Y.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-5793
Statut éditorial
Publié
Date de publication
1998-03
Volume
424
Numéro
1-2
Première page
33
Dernière page/numéro d’article
6
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar 6
Research Support, Non-U.S. Gov't --- Old month value: Mar 6
Résumé
The possible participation of calmodulin in the activation of store-operated Ca2+ entry (SOC) in single rat hepatocytes was investigated microspectrofluorimetrically. SOC was triggered after discharging intracellular Ca2+ stores using the endoplasmic reticulum Ca2+-ATPase inhibitor thapsigargin in the absence of external Ca2+. Re-admission of bath Ca2+ caused a rapid and pronounced Ca2+ entry. The calmodulin antagonists calmidazolium or CGS 9343B applied before the thapsigargin treatment inhibited SOC, whereas they were ineffective when added after the thapsigargin-induced Ca2+ transient. This study suggests that activation of calmodulin after the elevation of cytosolic Ca2+ associated with the emptying of Ca2+ stores is involved in the triggering of SOC in hepatocytes.
Sujets
PID Serval
serval:BIB_95441CD60400
PMID
Date de création
2008-01-24T12:08:36.272Z
Date de création dans IRIS
2025-05-20T23:05:48Z