Titre
Impact of biological and environmental variabilities on biological monitoring: an approach using toxicokinetic models
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Berthet, Aurélie
Auteure/Auteur
Batz Alice, de
Auteure/Auteur
Tardif, Robert
Auteure/Auteur
Charest-Tardif, Ginette
Auteure/Auteur
Truchon, Ginette
Auteure/Auteur
Vernez, David
Auteure/Auteur
Droz, Pierre-Olivier
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1545-9624
Statut éditorial
Publié
Date de publication
2010-03
Volume
7
Numéro
3
Première page
177
Dernière page/numéro d’article
184
Peer-reviewed
Oui
Langue
anglais
Résumé
Biological monitoring of occupational exposure is characterized by important variability, due both to variability in the environment and to biological differences between workers. A quantitative description and understanding of this variability is important for a dependable application of biological monitoring. This work describes this variability,using a toxicokinetic model, for a large range of chemicals for which reference biological reference values exist. A toxicokinetic compartmental model describing both the parent compound and its metabolites was used. For each chemical, compartments were given physiological meaning. Models were elaborated based on physiological, physicochemical, and biochemical data when available, and on half-lives and central compartment concentrations when not available. Fourteen chemicals were studied (arsenic, cadmium, carbon monoxide, chromium, cobalt, ethylbenzene, ethyleneglycol monomethylether, fluorides, lead, mercury, methyl isobutyl ketone, penthachlorophenol, phenol, and toluene), representing 20 biological indicators. Occupational exposures were simulated using Monte Carlo techniques with realistic distributions of both individual physiological parameters and exposure conditions. Resulting biological indicator levels were then analyzed to identify the contribution of environmental and biological variability to total variability. Comparison of predicted biological indicator levels with biological exposure limits showed a high correlation with the model for 19 out of 20 indicators. Variability associated with changes in exposure levels (GSD of 1.5 and 2.0) is shown to be mainly influenced by the kinetics of the biological indicator. Thus, with regard to variability, we can conclude that, for the 14 chemicals modeled, biological monitoring would be preferable to air monitoring. For short half-lives (less than 7 hr), this is very similar to the environmental variability. However, for longer half-lives, estimated variability decreased.
[Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource: tables detailing the CBTK models for all 14 chemicals and the symbol nomenclature that was used.] [Authors]
[Supplementary materials are available for this article. Go to the publisher's online edition of Journal of Occupational and Environmental Hygiene for the following free supplemental resource: tables detailing the CBTK models for all 14 chemicals and the symbol nomenclature that was used.] [Authors]
PID Serval
serval:BIB_87512999B29B
PMID
Open Access
Oui
Date de création
2011-01-04T08:57:48.550Z
Date de création dans IRIS
2025-05-20T23:08:53Z
Fichier(s)![Vignette d'image]()
En cours de chargement...
Nom
BIB_87512999B29B.P001.pdf
Version du manuscrit
postprint
Taille
156.33 KB
Format
Adobe PDF
PID Serval
serval:BIB_87512999B29B.P001
URN
urn:nbn:ch:serval-BIB_87512999B29B2
Somme de contrôle
(MD5):694091f520963b3e9ced3a71ecd52fb8