Titre
Characterization of pretransplant CTL activity in "perfectly matched" unrelated bone marrow donor/recipient combinations.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Rufer, N.
Auteure/Auteur
Tiercy, J.M.
Auteure/Auteur
Speiser, D.
Auteure/Auteur
Helg, C.
Auteure/Auteur
Gratwohl, A.
Auteure/Auteur
Chapuis, B.
Auteure/Auteur
Jeannet, M.
Auteure/Auteur
Roosnek, E.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0268-3369
Statut éditorial
Publié
Date de publication
1993
Volume
11
Numéro
Suppl. 1
Première page
20
Dernière page/numéro d’article
23
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
To characterize the pre-transplant cytotoxic T cell precursor (CTLp) activity of unrelated bone marrow donors towards their HLA-ABDR compatible recipients, we have established T cell clones from the primary (positive) CTLp cultures. Two "perfectly matched" oligo-typed DR/DQ identical combinations and two A/B identical, DR subtype incompatible combinations have been studied in detail. Analysis of the clones shows that in the first two combinations the alloreactivity was directed towards a subtype of A2 (A205) and a subtype of Bw60 respectively. In the other two cases, where class II incompatibilities were present, we have not yet defined the exact specificity. However, because the majority of recipient specific clones were of the CD8 phenotype, it is very likely that also in these two cases differences in class I are being recognized.
PID Serval
serval:BIB_D268B9139C39
PMID
Date de création
2008-01-28T10:33:30.694Z
Date de création dans IRIS
2025-05-20T23:21:40Z