Titre
Induction of the blood-brain barrier specific HT7 and neurothelin epitopes in endothelial cells of the chick chorioallantoic vessels by a soluble factor derived from astrocytes.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Brain research. Developmental brain research
Auteur(s)
Lobrinus, J.A.
Auteure/Auteur
Juillerat-Jeanneret, L.
Auteure/Auteur
Darekar, P.
Auteure/Auteur
Schlosshauer, B.
Auteure/Auteur
Janzer, R.C.
Auteure/Auteur
Liens vers les personnes
rjanzer
Liens vers les unités
ISSN
0165-3806
Statut éditorial
Publié
Date de publication
1992-12-18
Volume
70
Numéro
2
Première page
207
Dernière page/numéro d’article
211
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Some blood-brain barrier properties of microvascular endothelial cells have been shown to be inducible by astrocytes. We tested the hypothesis that this cellular interaction is mediated by a soluble factor(s). Chick chorioallantoic vessels in ovo were constantly exposed to astrocyte-conditioned medium. We found that endothelial cells exposed to astrocyte-derived factors, but not to glioma- or endothelial cell-derived factors, expressed the HT7 antigen and neurothelin, two specific markers of the blood-brain barrier phenotype. These results indicate that a soluble factor(s) secreted by astrocytes is capable to induce specific blood-brain barrier properties in endothelial cells of non-neural origin.
PID Serval
serval:BIB_CF040F88C6E7
PMID
Date de création
2008-01-29T17:35:12.676Z
Date de création dans IRIS
2025-05-20T23:54:20Z
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Nom
1282444.pdf
Version du manuscrit
published
Licence
https://iris.unil.ch/disclaimer
Taille
1.43 MB
Format
Adobe PDF
PID Serval
serval:BIB_CF040F88C6E7.P001
Somme de contrôle
(MD5):b8ca69569e1d0a81f2aca60a37ec744b