Titre
Acute cardiovascular effects of two central phenylethanolamine-N-methyl-transferase inhibitors in unanesthetized desoxycorticosterone-salt hypertensive rats
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Biollaz, B.
Auteure/Auteur
Biollaz, J.
Auteure/Auteur
Kohlman, O., Jr.,
Auteure/Auteur
Bresnahan, M.
Auteure/Auteur
Gavras, I.
Auteure/Auteur
Gavras, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-2999
Statut éditorial
Publié
Date de publication
1984-07
Volume
102
Numéro
3-4
Première page
515
Dernière page/numéro d’article
9
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 20
Research Support, Non-U.S. Gov't --- Old month value: Jul 20
Résumé
SKF 64139, an inhibitor of phenylethanolamine-N-methyltransferase (PNMT), has a marked hypotensive effect in models of sodium-dependent hypertension. The mechanism of this effect is obscure, the compound having in addition alpha-adrenoceptor blocking properties. We compared the acute effects of SKF 64139 with those of LY 134046, another PNMT inhibitor with minimal alpha-blocking capacity, in desoxycorticosterone-salt hypertensive rats. The former agent produced profound hypotension whereas the latter caused only bradycardia. Both induced a similar pronounced suppression of PNMT activity in the C1 and C2 region of the medulla oblongata. These results suggest that the alpha-adrenergic effect rather than PNMT inhibition accounts for the acute lowering of blood pressure in this model.
Sujets
PID Serval
serval:BIB_C3858F32EA76
PMID
Date de création
2008-01-25T09:41:34.256Z
Date de création dans IRIS
2025-05-20T23:55:21Z