Titre
Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Rizzoli, Ren
Auteure/Auteur
Laroche, Michel
Auteure/Auteur
Krieg, Marc-Antoine
Auteure/Auteur
Frieling, Isolde
Auteure/Auteur
Thomas, Thierry
Auteure/Auteur
Delmas, Pierre
Auteure/Auteur
Felsenberg, Dieter
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1437-160X[electronic], 0172-8172[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
30
Numéro
10
Première page
1341
Dernière page/numéro d’article
1348
Langue
anglais
Résumé
The structural basis of the antifracture efficacy of strontium ranelate and alendronate is incompletely understood. We compared the effects of strontium ranelate and alendronate on distal tibia microstructure over 2 years using HR-pQCT. In this pre-planned, interim, intention-to-treat analysis at 12 months, 88 osteoporotic postmenopausal women (mean age 63.7 +/- 7.4) were randomized to strontium ranelate 2 g/day or alendronate 70 mg/week in a double-placebo design. Primary endpoints were changes in microstructure. Secondary endpoints included lumbar and hip areal bone mineral density (aBMD), and bone turnover markers. This trial is registered with http://www.controlled-trials.com, number ISRCTN82719233. Baseline characteristics of the two groups were similar. Treatment with strontium ranelate was associated with increases in mean cortical thickness (CTh, 5.3%), cortical area (4.9%) and trabecular density (2.1%) (all P < 0.001, except cortical area P = 0.013). No significant changes were observed with alendronate. Between-group differences in favor of strontium ranelate were observed for CTh, cortical area, BV/TV and trabecular density (P = 0.045, 0.041, 0.048 and 0.035, respectively). aBMD increased to a similar extent with strontium ranelate and alendronate at the spine (5.7% versus 5.1%, respectively) and total hip (3.3% versus 2.2%, respectively). No significant changes were observed in remodeling markers with strontium ranelate, while suppression was observed with alendronate. Within the methodological constraints of HR-pQCT through its possible sensitivity to X-ray attenuation of different minerals, strontium ranelate had greater effects than alendronate on distal tibia cortical thickness and trabecular volumetric density.
PID Serval
serval:BIB_6265893B0A91
PMID
Open Access
Oui
Date de création
2010-08-18T09:33:47.534Z
Date de création dans IRIS
2025-05-21T00:19:59Z
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Nom
BIB_6265893B0A91.P001.pdf
Version du manuscrit
preprint
Taille
351.17 KB
Format
Adobe PDF
PID Serval
serval:BIB_6265893B0A91.P001
URN
urn:nbn:ch:serval-BIB_6265893B0A911
Somme de contrôle
(MD5):ef35bc4b98a92f33fc9e0c616b3ae571