Titre
New infectious mammary tumor virus superantigen with V beta-specificity identical to staphylococcal enterotoxin B (SEB).
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Luther, S.
Auteure/Auteur
Shakhov, A.N.
Auteure/Auteur
Xenarios, I.
Auteure/Auteur
Haga, S.
Auteure/Auteur
Imai, S.
Auteure/Auteur
Acha-Orbea, H.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0014-2980
Statut éditorial
Publié
Date de publication
1994
Volume
24
Numéro
8
Première page
1757
Dernière page/numéro d’article
1764
Langue
anglais
Résumé
Only few infectious mouse mammary tumor viruses (MMTV) have been characterized which induce a potent superantigen response in vivo. Here we describe the characterization of an MMTV which was isolated from milk of the highly mammary tumor-prone SHN mouse strain. Exposure of newborn mice to milk-borne MMTV (SHN) results in a very slow deletion of V beta 7, 8.1, 8.2 and 8.3 expressing peripheral T cells. Subcutaneous injection of adult mice with this virus induces a rapid and strong stimulation of all four affected V beta-subsets in vivo. Besides the strong T cell effect we observed an early proliferation and activation of the local B cell pool leading to the initial secretion of IgM followed by preferential secretion of IgG2a by day 6. Sequence comparison of the polymorphic C terminus with known open reading frames revealed high homology to the endogenous provirus Mtv-RCS. This is the first report of a virus having a complete overlap in V beta-specificity with a bacterial superantigen stimulating as many as 35% of the whole CD4+ T cell repertoire including V beta 8.2.
Sujets
PID Serval
serval:BIB_A37111576A06
PMID
Date de création
2008-01-24T13:48:30.144Z
Date de création dans IRIS
2025-05-21T00:38:56Z