Titre
Candida albicans and Pseudomonas aeruginosa interactions: more than an opportunistic criminal association?
Type
article
Institution
Externe
Périodique
Auteur(s)
Méar, J.B.
Auteure/Auteur
Kipnis, E.
Auteure/Auteur
Faure, E.
Auteure/Auteur
Dessein, R.
Auteure/Auteur
Schurtz, G.
Auteure/Auteur
Faure, K.
Auteure/Auteur
Guery, B.
Auteure/Auteur
Liens vers les personnes
ISSN
1769-6690
Statut éditorial
Publié
Date de publication
2013-04
Volume
43
Numéro
4
Première page
146
Dernière page/numéro d’article
151
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Pseudomonas aeruginosa and Candida albicans are frequently coexisting opportunistic pathogens, responsible for colonization and infection in predisposed patients. They share a virulence specificity relying on auto-inducing, cell density-dependent molecules named quorum-sensing (QS). C. albicans virulence depends on its QS that influences morphological switch from yeast to filamentous form. Similarly, the production of P. aeruginosa virulence factors depends partly on QS molecules. Interactions have been investigated and demonstrated in vitro. P. aeruginosa may kill C. albicans either by producing toxins, such as pyocyanin, or by direct contact on its biofilm-dependent filamentous form. Cross-kingdom communication is a more subtle interaction: C. albicans can adapt its morphology in the presence of P. aeruginosa QS molecules, and inhibit P. aeruginosa QS-dependent virulence factor secretion, through farnesol, one of its QS molecule. But the in vivo relevance of these interactions is still controversial, as models of airway colonization/infection by C. albicans followed by subsequent P. aeruginosa pneumonia give contradictory results, suggesting the probable involvement of the immune system as a third party player. Finally, the authors of clinical studies performed in ventilated patients, indicate that C. albicans colonization could be a risk factor for P. aeruginosa pneumonia. The clinical outcome of C. albicans and P. aeruginosa interaction is uncertain, the virulence modulation demonstrated in these interactions opens new possibilities for future anti-infectious therapeutics.
PID Serval
serval:BIB_9757D8D0CF8E
PMID
Open Access
Oui
Date de création
2021-04-29T08:59:31.491Z
Date de création dans IRIS
2025-05-21T00:44:46Z