Titre
The Evaluation of BMI1 Posttranslational Modifications During Retinal Degeneration to Understand BMI1 Action on Photoreceptor Death Execution.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Advances in experimental medicine and biology
Auteur(s)
Mbefo, M.K.
Auteure/Auteur
Arsenijevic, Y.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0065-2598
Statut éditorial
Publié
Date de publication
2018
Volume
1074
Première page
359
Dernière page/numéro d’article
365
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Retinitis Pigmentosa (RP) is a class of hereditary retinal dystrophy associated with gradual visual failure and a subsequent loss of light-sensitive cells in the retina, leading to blindness. Many mutated genes were found to be causative of this disease. Despite a number of compiling efforts, the process of cell death in photoreceptors remains to be clearly elucidated. We recently reported an abnormal cell cycle reentry in photoreceptors undergoing degeneration in Rd1 mice, a model of RP, and identified the polycomb repressive complex 1 (PRC1) core component BMI1 as a critical molecular factor orchestrating the cell death mechanism. As the cell death rescue in Rd1;Bmi-1 KO mice was independent on the conventional Ink4a/Arf pathways, we now explored the structural properties of BMI1 in order to examine the differential expression of its posttranslational modifications in Rd1 retina. Our results suggest that BMI1 cell death induction in Rd1 is not related to its phosphorylation status. We therefore propose the epigenetic activity of BMI1 as an alternative route for BMI1-mediated toxicity in Rd1.
Sujets
PID Serval
serval:BIB_8AE7D5B14042
PMID
Date de création
2018-05-12T09:18:57.554Z
Date de création dans IRIS
2025-05-21T01:06:48Z