Titre
MHC presentation via autophagy and how viruses escape from it
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Gannage, M.
Auteure/Auteur
Munz, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1863-2300
Statut éditorial
Publié
Date de publication
2010-12
Volume
32
Numéro
4
Première page
373
Dernière page/numéro d’article
81
Langue
anglais
Notes
Gannage, Monique
Munz, Christian
eng
R01 CA108609/CA/NCI NIH HHS/
R01CA101741/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Germany
Semin Immunopathol. 2010 Dec;32(4):373-81. doi: 10.1007/s00281-010-0227-7. Epub 2010 Sep 21.
Munz, Christian
eng
R01 CA108609/CA/NCI NIH HHS/
R01CA101741/CA/NCI NIH HHS/
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Germany
Semin Immunopathol. 2010 Dec;32(4):373-81. doi: 10.1007/s00281-010-0227-7. Epub 2010 Sep 21.
Résumé
T cells detect infected and transformed cells via antigen presentation by major histocompatibility complex (MHC) molecules on the cell surface. For T cell stimulation, these MHC molecules present fragments of proteins that are expressed or taken up by the cell. These fragments are generated by distinct proteolytic mechanisms for presentation on MHC class I molecules to cytotoxic CD8(+) and on MHC class II molecules to helper CD4(+) T cells. Proteasomes are primarily involved in MHC class I ligand and lysosomes, in MHC class II ligand generation. Autophagy delivers cytoplasmic material to lysosomes and, therefore, contributes to cytoplasmic antigen presentation by MHC class II molecules. In addition, it has been recently realized that this process also supports extracellular antigen processing for MHC class II presentation and cross-presentation on MHC class I molecules. Although the exact mechanisms for the regulation of these antigen processing pathways by autophagy are still unknown, recent studies, summarized in this review, suggest that they contribute to immune responses against infections and to maintain tolerance. Moreover, they are targeted by viruses for immune escape and could maybe be harnessed for immunotherapy.
PID Serval
serval:BIB_844A66409BD6
PMID
Date de création
2022-03-10T09:43:27.557Z
Date de création dans IRIS
2025-05-21T01:08:39Z