Titre
Crosstalk between neutrophils and dendritic cells: a context-dependent process.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Schuster, S.
Auteure/Auteur
Hurrell, B.
Auteure/Auteur
Tacchini-Cottier, F.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1938-3673
Statut éditorial
Publié
Date de publication
2013
Volume
94
Numéro
4
Première page
671
Dernière page/numéro d’article
675
Langue
anglais
Résumé
Neutrophils are massively and rapidly recruited following infection. They migrate to the site of acute infection and also transiently to dLNs. In addition to their well-established role as microbial killers, accumulating evidence shows that neutrophils can play an immunoregulatory role. Neutrophils were recently shown to influence the activation of different leukocyte types including NK cells, B cells, and DCs. DCs are professional APCs playing a key role to the launching and regulation of the immune response; thus, crosstalk between neutrophils and resident or newly recruited DCs may have a direct impact on the development of the antigen-specific immune response and thereby, on the outcome of infection. Neutrophils may regulate DC recruitment and/or activation. We will review here recent progress in the field, including those presented during the first international symposium on "Neutrophil in Immunity", held in Québec, Canada, in June 2012, and discuss how neutrophil regulatory action on DCs may differ depending on the type of invading microorganism and local host factors.
PID Serval
serval:BIB_B1A609D3DF26
PMID
Open Access
Oui
Date de création
2014-01-07T13:17:14.060Z
Date de création dans IRIS
2025-05-21T01:14:59Z