Titre
Cholangiolocellular carcinoma: an innocent-looking malignant liver tumor mimicking ductular reaction.
Type
étude de cas
Institution
Externe
Périodique
Auteur(s)
Sempoux, C.
Auteure/Auteur
Fan, C.
Auteure/Auteur
Singh, P.
Auteure/Auteur
Obeidat, K.
Auteure/Auteur
Roayaie, S.
Auteure/Auteur
Schwartz, M.
Auteure/Auteur
Fiel, M.I.
Auteure/Auteur
Thung, S.N.
Auteure/Auteur
Liens vers les personnes
ISSN
1098-8971
Statut éditorial
Publié
Date de publication
2011
Volume
31
Numéro
1
Première page
104
Dernière page/numéro d’article
110
Langue
anglais
Notes
Publication types: Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
The authors present an interesting case of a 60-year-old man who underwent right hepatectomy for a diagnosis of hepatocellular carcinoma (HCC) on a background of noncirrhotic chronic hepatitis C. Pathologic examination confirmed the presence of HCC near the porta hepatis, which invaded the right portal vein branch. In addition, a well-demarcated 13.5 × 7.8 × 4.0 cm yellow and firm area upstream of the HCC was noted. This yellow area corresponded to a tumoral ductular proliferation, which cytologically was extremely bland, but invaded portal tracts and the adjacent liver parenchyma. This tumoral proliferation mimicked ductular reaction, except that it had more anastomosing structures and was associated with abundant hyalinized fibrotic stroma. Cytologically, the tumor cells had round to oval nuclei with fine chromatin, indistinct nucleoli, and scant cytoplasm. They exhibited immunohistochemical features of hepatic progenitor cells, i.e., expressing CK7, CK19, and N-CAM; and their malignancy was supported by the p53 and Ki67 immunoreactivity. The authors concluded that the patient had cholangiolocellular carcinoma with an aggressive hepatocellular carcinoma component. Cholangiolocellular carcinoma has been reported to be associated with chronic hepatitis C viral infection and to derive from hepatic progenitor cells, which explains why hepatocellular carcinoma and/or cholangiocarcinoma component may be present.
Sujets
PID Serval
serval:BIB_CE84CE463EA3
PMID
Date de création
2015-01-19T09:49:12.148Z
Date de création dans IRIS
2025-05-21T01:29:06Z