Titre
Fetal lung growth in experimental utero-abdominal pregnancy
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Moessinger, A. C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0029-7844
Statut éditorial
Publié
Date de publication
1986-11
Volume
68
Numéro
5
Première page
675
Dernière page/numéro d’article
8
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Résumé
We removed rat fetuses from the uterus without disturbing the placental implantation site, placing the fetuses in the peritoneal cavity either within intact membranes (with or without amniotic fluid) or outside of the fetal membranes. Untouched littermate fetuses served as controls. The surgery was performed on day 17 of gestation and the outcome was analyzed at term, 4 days later. The utero-abdominal pregnancies with intact membranes and amniotic fluid yielded fetuses in all respects indistinguishable from littermate controls. Extrauterine fetuses maintained within their membranes but without amniotic fluid as well as extrauterine and extramembranous fetuses displayed identical features: body weight was slightly reduced; after correction for body weight, only their lungs weighed significantly less and contained less deoxyribonucleic acid. In addition, fetuses in these two groups had multiple joint contractures and occasional webbing of the skin. These experimental findings in rats indicate an important role of amniotic fluid in fetal development, especially of the lung.
Sujets
PID Serval
serval:BIB_7C988CF5706C
PMID
Date de création
2008-01-25T12:16:53.903Z
Date de création dans IRIS
2025-05-21T01:41:12Z