Titre
Enzyme polymorphism and clinical variability of diseases: a study of diabetes mellitus.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Gloria-Bottini, F.
Auteure/Auteur
Gerlini, G.
Auteure/Auteur
Lucarini, N.
Auteure/Auteur
Borgiani, P.
Auteure/Auteur
Gori, M.C.
Auteure/Auteur
Amante, A.
Auteure/Auteur
Bottini, E.
Auteure/Auteur
Liens vers les unités
ISSN
0018-7143
Statut éditorial
Publié
Date de publication
1989
Volume
61
Numéro
4
Première page
571
Dernière page/numéro d’article
589
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
We investigated possible relations among four common neonatal manifestations of diabetic pregnancy (macrosomia, hypoglycemia, hypocalcemia, jaundice) and four enzyme polymorphisms (PGM1, ADA, AK1, ACP1 in a sample of infants born of diabetic mothers. The pattern of associations observed between the two sets of variables is consistent with known differences in enzymatic activity within phenotypes of each system, suggesting that low enzymatic activity may have unfavorable effects on fetal development and on adaptability of the neonate to the extrauterine environment, Some of the polymorphic enzymes studied influence fetal growth in normal pregnancy as well. Analysis of relations between genetic polymorphisms and the clinical pattern of common diseases may provide a better understanding of the genetic basis of the clinical variability of diseases within and between human populations.
PID Serval
serval:BIB_C37E0D3640A1
PMID
Date de création
2015-02-11T09:43:29.913Z
Date de création dans IRIS
2025-05-21T02:02:58Z