Titre
Bystander activation of CD4+ T cells.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Boyman, O.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1521-4141[electronic], 0014-2980[linking]
Statut éditorial
Publié
Date de publication
2010
Volume
40
Numéro
4
Première page
936
Dernière page/numéro d’article
939
Langue
anglais
Notes
Publication types: Comment ; Journal Article ; Research Support, Non-U.S. Gov't Publication Status: ppublish
Résumé
Bystander activation of T cells, i.e. the stimulation of unrelated (heterologous) T cells by cytokines during an Ag-specific T-cell response, has been best described for CD8(+) T cells. In the CD8(+) compartment, the release of IFN and IFN-inducers leads to the production of IL-15, which mediates the proliferation of CD8(+) T cells, notably memory-phenotype CD8(+) T cells. CD4(+) T cells also undergo bystander activation, however, the signals inducing this Ag-nonspecific stimulation of CD4(+) T cells are less well known. A study in this issue of the European Journal of Immunology sheds light on this aspect, suggesting that common gamma-chain cytokines including IL-2 might be involved in bystander activation of CD4(+) T cells.
Sujets
PID Serval
serval:BIB_C393733487BC
PMID
Open Access
Oui
Date de création
2011-06-15T09:27:51.430Z
Date de création dans IRIS
2025-05-21T02:03:07Z