Titre
Prospective validation in epithelial tumors of a gene expression predictor of liver metastasis derived from uveal melanoma.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Tsantoulis, P.
Auteure/Auteur
Delorenzi, M.
Auteure/Auteur
Bièche, I.
Auteure/Auteur
Vacher, S.
Auteure/Auteur
Mariani, P.
Auteure/Auteur
Cassoux, N.
Auteure/Auteur
Houy, A.
Auteure/Auteur
Stern, M.H.
Auteure/Auteur
Roman-Roman, S.
Auteure/Auteur
Dietrich, P.Y.
Auteure/Auteur
Roth, A.
Auteure/Auteur
Cacheux, W.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2019-11-20
Volume
9
Numéro
1
Première page
17178
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: epublish
Publication Status: epublish
Résumé
Predicting the risk of liver metastasis can have important prognostic and therapeutic implications, given the availability of liver-directed therapy. Uveal melanoma has a striking predisposition for liver metastasis despite the absence of anatomical proximity. Understanding its biology may uncover factors promoting liver metastasis in other malignancies. We quantified gene expression by RNAseq in 76 uveal melanomas and combined with public data in a meta-analysis of 196 patients. The meta-analysis of uveal melanoma gene expression identified 63 genes which remained prognostic after adjustment for chromosome 3 status. Two genes, PTP4A3 and JPH1, were selected by L1-penalized regression and combined in a prognostic score. The score predicted liver-specific relapse in a public pan-cancer dataset and in two public colorectal cancer datasets. The score varied between colorectal consensus molecular subtypes (CMS), as did the risk of liver relapse, which was lowest in CMS1. Additional prospective validation was done by real-time PCR in 463 breast cancer patients. The score was significantly correlated with liver relapse in hormone receptor positive tumors. In conclusion, the expression of PTP4A3 and JPH1 correlates with risk of liver metastasis in colorectal cancer and breast cancer. The underlying biological mechanism is an interesting area for further research.
PID Serval
serval:BIB_B2ADA6C4E5AE
PMID
Open Access
Oui
Date de création
2019-11-30T11:38:32.575Z
Date de création dans IRIS
2025-05-21T02:18:07Z
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Nom
31748560_BIB_B2ADA6C4E5AE.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
2.63 MB
Format
Adobe PDF
PID Serval
serval:BIB_B2ADA6C4E5AE.P001
URN
urn:nbn:ch:serval-BIB_B2ADA6C4E5AE2
Somme de contrôle
(MD5):3a7cc5144018f23f70c5b39602bb3cfd