Titre
Gene Ontology: Pitfalls, Biases, and Remedies.
Type
chapitre
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Auteur(s)
Gaudet, P.
Auteure/Auteur
Dessimoz, C.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
Maison d’édition
Springer
Titre du livre ou conférence/colloque
Methods in molecular biology
Statut éditorial
Date de publication
2017
Volume
1446
Chapitre
14
Première page
189
Dernière page/numéro d’article
205
Peer-reviewed
Langue
anglais
Résumé
The Gene Ontology (GO) is a formidable resource, but there are several considerations about it that are essential to understand the data and interpret it correctly. The GO is sufficiently simple that it can be used without deep understanding of its structure or how it is developed, which is both a strength and a weakness. In this chapter, we discuss some common misinterpretations of the ontology and the annotations. A better understanding of the pitfalls and the biases in the GO should help users make the most of this very rich resource. We also review some of the misconceptions and misleading assumptions commonly made about GO, including the effect of data incompleteness, the importance of annotation qualifiers, and the transitivity or lack thereof associated with different ontology relations. We also discuss several biases that can confound aggregate analyses such as gene enrichment analyses. For each of these pitfalls and biases, we suggest remedies and best practices.
PID Serval
serval:BIB_CBFCF5FD756A
PMID
Date de création
2016-11-30T20:38:48.730Z
Date de création dans IRIS
2025-05-21T02:23:49Z
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Nom
978-1-4939-3743-1_14 (1).pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
436.87 KB
Format
Adobe PDF
PID Serval
serval:BIB_CBFCF5FD756A.P001
URN
urn:nbn:ch:serval-BIB_CBFCF5FD756A7
Somme de contrôle
(MD5):b9fda1ca870b057dfa5a4575d21f5130