Titre
CEP-1347/KT7515, a JNK pathway inhibitor, supports the in vitro survival of chick embryonic neurons.
Type
article
Institution
Externe
Périodique
Auteur(s)
Borasio, G.D.
Auteure/Auteur
Horstmann, S.
Auteure/Auteur
Anneser, J.M.
Auteure/Auteur
Neff, N.T.
Auteure/Auteur
Glicksman, M.A.
Auteure/Auteur
Liens vers les personnes
ISSN
0959-4965
Statut éditorial
Publié
Date de publication
1998
Volume
9
Numéro
7
Première page
1435
Dernière page/numéro d’article
1439
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Developing neurons depend on target-derived trophic factors for survival in vivo and in vitro, which also decrease the activity of c-Jun N-terminal kinase (JNK). We have recently described a survival-promoting effect of inhibitors of cyclin-dependent kinases and JNK on chick peripheral embryonic neurons. Here, we report that the small trophic molecule CEP-1347/KT7515, which has been shown to inhibit the JNK signalling pathway, can promote long term-survival of cultured chick embryonic dorsal root ganglion, sympathetic, ciliary and motor neurons. Because of their pharmacological properties, small trophic molecules such as CEP-1347/KT7515 might be of interest for the treatment of neurodegenerative disorders.
Sujets
PID Serval
serval:BIB_D6F4AC585870
PMID
Date de création
2014-01-13T15:56:41.744Z
Date de création dans IRIS
2025-05-21T02:56:10Z