Titre
Optical coherence tomography as a biomarker of neurodegeneration in multiple sclerosis: A review.
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Alonso, R.
Auteure/Auteur
Gonzalez-Moron, D.
Auteure/Auteur
Garcea, O.
Auteure/Auteur
Liens vers les unités
ISSN
2211-0356
Statut éditorial
Publié
Date de publication
2018-05
Volume
22
Première page
77
Dernière page/numéro d’article
82
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Publication Status: ppublish
Résumé
Neurodegeneration is one the most important pathological factors which contributes to permanent disability in multiple sclerosis (MS). Optical coherence tomography (OCT) measurements of macular ganglion cell layer (mGCL) and retinal nerve fiber layer (RNFL) have been proposed as biomarkers of axonal damage in MS. The aim of this review is to describe the most relevant findings regarding OCT and axonal damage in MS. We have selected studies that describe retina impairment in MS patients, and those which quantitatively assess the relationship between OCT and physical disability, cognitive impairment and relationship between OCT and magnetic resonance imaging (MRI). Results show that there is a relationship between the degree of retinal layers reduction and physical or cognitive disability and degenerative changes in MRI.
PID Serval
serval:BIB_E5187C3BED15
PMID
Date de création
2018-04-12T16:03:13.200Z
Date de création dans IRIS
2025-05-21T03:06:34Z