Titre
An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation.
Type
recension de livre
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kapun, M.
Auteure/Auteur
Mitchell, E.D.
Auteure/Auteur
Kawecki, T.J.
Auteure/Auteur
Schmidt, P.
Auteure/Auteur
Flatt, T.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1537-1719
Statut éditorial
Publié
Date de publication
2023-06-01
Volume
40
Numéro
6
Première page
msad11
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
Since the pioneering work of Dobzhansky in the 1930s and 1940s, many chromosomal inversions have been identified, but how they contribute to adaptation remains poorly understood. In Drosophila melanogaster, the widespread inversion polymorphism In(3R)Payne underpins latitudinal clines in fitness traits on multiple continents. Here, we use single-individual whole-genome sequencing, transcriptomics, and published sequencing data to study the population genomics of this inversion on four continents: in its ancestral African range and in derived populations in Europe, North America, and Australia. Our results confirm that this inversion originated in sub-Saharan Africa and subsequently became cosmopolitan; we observe marked monophyletic divergence of inverted and noninverted karyotypes, with some substructure among inverted chromosomes between continents. Despite divergent evolution of this inversion since its out-of-Africa migration, derived non-African populations exhibit similar patterns of long-range linkage disequilibrium between the inversion breakpoints and major peaks of divergence in its center, consistent with balancing selection and suggesting that the inversion harbors alleles that are maintained by selection on several continents. Using RNA-sequencing, we identify overlap between inversion-linked single-nucleotide polymorphisms and loci that are differentially expressed between inverted and noninverted chromosomes. Expression levels are higher for inverted chromosomes at low temperature, suggesting loss of buffering or compensatory plasticity and consistent with higher inversion frequency in warm climates. Our results suggest that this ancestrally tropical balanced polymorphism spread around the world and became latitudinally assorted along similar but independent climatic gradients, always being frequent in subtropical/tropical areas but rare or absent in temperate climates.
PID Serval
serval:BIB_B1F073DBC8A2
PMID
Open Access
Oui
Date de création
2023-05-31T06:59:43.562Z
Date de création dans IRIS
2025-05-21T03:20:36Z
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Nom
37220650_BIB_B1F073DBC8A2.pdf
Version du manuscrit
published
Licence
https://creativecommons.org/licenses/by/4.0
Taille
13.02 MB
Format
Adobe PDF
PID Serval
serval:BIB_B1F073DBC8A2.P001
URN
urn:nbn:ch:serval-BIB_B1F073DBC8A28
Somme de contrôle
(MD5):8876eb754ee7c7d76d3a26dc479d1031