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  4. Irritability in pre-clinical Huntington's disease.
 
  • Détails
Titre

Irritability in pre-clinical Huntington's disease.

Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Neuropsychologia  
Auteur(s)
Klöppel, S.
Auteure/Auteur
Stonnington, C.M.
Auteure/Auteur
Petrovic, P.
Auteure/Auteur
Mobbs, D.
Auteure/Auteur
Tüscher, O.
Auteure/Auteur
Craufurd, D.
Auteure/Auteur
Tabrizi, S.J.
Auteure/Auteur
Frackowiak, R.S.
Auteure/Auteur
Liens vers les personnes
Frackowiak, Richard  
Liens vers les unités
Neurologie  
ISSN
1873-3514
Statut éditorial
Publié
Date de publication
2010-01
Volume
48
Numéro
2
Première page
549
Dernière page/numéro d’article
557
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
Irritability, together with depression and anxiety, form three salient clinical features of pre-symptomatic Huntington's disease (HD). To date, the understanding of irritability in HD suffers from a paucity of experimental data and is largely based on questionnaires or clinical anecdotes. Factor analysis suggests that irritability is related to impulsivity and aggression and is likely to engage the same neuronal circuits as these behaviours, including areas such as medial orbitofrontal cortex (OFC) and amygdala. 16 pre-symptomatic gene carriers (PSCs) and 15 of their companions were asked to indicate the larger of two squares consecutively shown on a screen while undergoing functional magnetic resonance imaging (fMRI). Despite correct identification of the larger square, participants were often told that they or their partner had given the wrong answer. Size differences were subtle to make negative feedback credible but detectable. Although task performance, baseline irritability, and reported task-induced irritation were the same for both groups, fMRI revealed distinct neuronal processing in those who will later develop HD. In controls but not PSCs, task-induced irritation correlated positively with amygdala activation and negatively with OFC activation. Repetitive negative feedback induced greater amygdala activations in controls than PSCs. In addition, the inverse functional coupling between amygdala and OFC was significantly weaker in PSCs compared to controls. Our results argue that normal emotion processing circuits are disrupted in PSCs via attenuated modulation of emotional status by external or internal indicators. At later stages, this dysfunction may increase the risk for developing recognised, HD-associated, psychiatric symptoms such as irritability.
Sujets

Adult

Brain Mapping

Chi-Square Distributi...

Feedback, Physiologic...

Female

Humans

Huntington Disease/di...

Huntington Disease/ge...

Huntington Disease/ph...

Image Processing, Com...

Irritable Mood/physio...

Magnetic Resonance Im...

Male

Middle Aged

Oxygen/blood

Sex Factors

Statistics as Topic

Surveys and Questionn...

Time Factors

PID Serval
serval:BIB_B25626477214
DOI
10.1016/j.neuropsychologia.2009.10.016
PMID
19878688
WOS
000274371700022
Permalien
https://iris.unil.ch/handle/iris/209228
Open Access
Oui
Date de création
2010-03-02T13:17:27.273Z
Date de création dans IRIS
2025-05-21T03:20:43Z
Fichier(s)
En cours de chargement...
Vignette d'image
Nom

19878688_BIB_B25626477214.pdf

Version du manuscrit

published

Taille

664.27 KB

Format

Adobe PDF

PID Serval

serval:BIB_B25626477214.P001

URN

urn:nbn:ch:serval-BIB_B256264772146

Somme de contrôle

(MD5):ee4bc97b3208942aecdab700befdf18d

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