Titre
Delivery systems and adjuvants for vaccination against HIV
Type
synthèse (review)
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
EXS
Auteur(s)
Velin, D.
Auteure/Auteur
Kraehenbuhl, J. P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1023-294X
Statut éditorial
Publié
Date de publication
2000
Volume
89
Première page
227
Dernière page/numéro d’article
37
Notes
Journal Article
Research Support, Non-U.S. Gov't
Review
Research Support, Non-U.S. Gov't
Review
Résumé
Epidemiological studies have revealed that HIV-1 infections occur through contact with contaminated blood or during unprotected vaginal or anal intercourse. Hence, to protect against HIV infection, vaccines should ideally induce both mucosal and systemic immune responses. We present a brief review of the different delivery systems and adjuvants which can be used to elicit mucosal immune responses. Oral or nasal administration of recombinant attenuated bacteria or viruses can induce both mucosal and systemic immune responses against the carried antigen. The oral delivery of mucosal adjuvants (such as cholera toxin) in association with antigens has been shown to enhance mucosal and systemic immune responses against them. Recently developed vaccination strategies using naked DNA or other antigen delivery systems are also discussed.
Sujets
PID Serval
serval:BIB_C0707493C4EF
PMID
Date de création
2008-01-25T15:10:09.730Z
Date de création dans IRIS
2025-05-21T03:26:49Z