Titre
Evolution of choroidal thickness over time and effect of early and sustained therapy in birdshot retinochoroiditis.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Skvortsova, N.
Auteure/Auteur
Gasc, A.
Auteure/Auteur
Jeannin, B.
Auteure/Auteur
Herbort, C.P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1476-5454
Statut éditorial
Publié
Date de publication
2017-08
Volume
31
Numéro
8
Première page
1205
Dernière page/numéro d’article
1211
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
PurposeTo follow choroidal thickness (ChT) over time in birdshot retinochoroiditis (BRC) using enhanced depth imaging optical coherence tomography (EDI-OCT) and study the effect of early and sustained treatment on ChT.Patients and methodsEighteen patients were included and EDI-OCT measurements of ChT were analyzed retrospectively in five groups of patients with follow-up times ranging from 1 year to ≥15 years. The OCT images were evaluated and ChT was calculated under the foveola and 1500 μm temporal, nasal, superior, and inferior to the foveola. To assess the effect of treatment, 13 patients with a disease duration ≥10 years were divided into two groups depending on their treatment status: early and sustained therapy vs insufficient, late, or no treatment. ChT was compared in these two groups along with the number of typical fundus BRC lesions.ResultsThe ChT decreased (r=-0.41, P=0.0018) over the disease duration, which ranged from <1 year to ≥15 years. In patients with a disease duration ≥10 years, a significant difference in ChT was noted between adequately and undertreated patients (288.3±76.9 μm vs 161.4±39.2 μm; P=0.004). At the last follow-up, in the group with insufficient therapy 10 of 11 eyes presented typical fundus BRC lesions vs 2 of 13 eyes in the treated group (P≤0.0006, F-test).ConclusionsChoroidal thickness decreases significantly over time in BRC. If undertreated, patients show thinner choroids compared with adequately treated individuals and present significantly more BRC lesions.
Sujets
PID Serval
serval:BIB_942D951F02F4
PMID
Open Access
Oui
Date de création
2017-04-29T15:09:11.520Z
Date de création dans IRIS
2025-05-21T03:44:49Z
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Nom
28430182_BIB_942D951F02F4.pdf
Version du manuscrit
published
Taille
1010.09 KB
Format
Adobe PDF
PID Serval
serval:BIB_942D951F02F4.P001
URN
urn:nbn:ch:serval-BIB_942D951F02F42
Somme de contrôle
(MD5):7023a54fbcfd52616482f6bec30acb35