Titre
Expression of human papillomavirus 16 E2 protein in Schizosaccharomyces pombe delays the initiation of mitosis
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Fournier, N.
Auteure/Auteur
Raj, K.
Auteure/Auteur
Saudan, P.
Auteure/Auteur
Utzig, S.
Auteure/Auteur
Sahli, R.
Auteure/Auteur
Simanis, V.
Auteure/Auteur
Beard, P.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0950-9232
Statut éditorial
Publié
Date de publication
1999-07
Volume
18
Numéro
27
Première page
4015
Dernière page/numéro d’article
21
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Jul 8
Research Support, Non-U.S. Gov't --- Old month value: Jul 8
Résumé
Infection by some types of human papillomavirus (HPV) is associated with the development of cervical cancer. Analysis of viral DNA from cervical tumours shows that the E2 gene is frequently disrupted during integration into the host cell's DNA. It has therefore been suggested that loss of E2p is an important step in malignant transformation. Expression of E2p in the fission yeast Schizosaccharomyces pombe retards the G2-M transition, by delaying activation of Cdc2p kinase. In contrast, S phase progression, and commitment to cell division in late G1 are not affected. The delay is independent of the transcriptional trans-activation function of E2p, and does not result from E2p DNA binding mimicking DNA damage. Increased expression of E2p also delays mitotic initiation in mammalian cells. S. pombe may thus provide a simple model for the analysis of E2p function.
Sujets
PID Serval
serval:BIB_6DFFB9F58C23
PMID
Open Access
Oui
Date de création
2008-01-24T19:51:22.546Z
Date de création dans IRIS
2025-05-21T04:07:41Z