Titre
Effect of sodium loading/depletion on renal oxygenation in young normotensive and hypertensive men.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Pruijm, M.
Auteure/Auteur
Hofmann, L.
Auteure/Auteur
Maillard, M.
Auteure/Auteur
Tremblay, S.
Auteure/Auteur
Glatz, N.
Auteure/Auteur
Wuerzner, G.
Auteure/Auteur
Burnier, M.
Auteure/Auteur
Vogt, B.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1524-4563
Statut éditorial
Publié
Date de publication
2010
Volume
55
Numéro
5
Première page
1116
Dernière page/numéro d’article
1122
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Publication Status: ppublish
Résumé
The goal of this study was to investigate the effect of sodium intake on renal tissue oxygenation in humans. To this purpose, we measured renal hemodynamics, renal sodium handling, and renal oxygenation in normotensive (NT) and hypertensive (HT) subjects after 1 week of a high-sodium and 1 week of a low-sodium diet. Renal oxygenation was measured using blood oxygen level-dependent magnetic resonance. Tissue oxygenation was determined by the measurement of R2* maps on 4 coronal slices covering both kidneys. The mean R2* values in the medulla and cortex were calculated, with a low R2* indicating a high tissue oxygenation. Ten male NT (mean age: 26.5+/-7.4 years) and 8 matched HT subjects (mean age: 28.8+/-5.7 years) were studied. Cortical R2* was not different under the 2 conditions of salt intake. Medullary R2* was significantly lower under low sodium than high sodium in both NT and HT subjects (28.1+/-0.8 versus 31.3+/-0.6 s(-1); P<0.05 in NT; and 27.9+/-1.5 versus 30.3+/-0.8 s(-1); P<0.05, in HT), indicating higher medullary oxygenation under low-sodium conditions. In NT subjects, medullary oxygenation was positively correlated with proximal reabsorption of sodium and negatively with absolute distal sodium reabsorption, but not with renal plasma flow. In HT subjects, medullary oxygenation correlated with the 24-hour sodium excretion but not with proximal or with the distal handling of sodium. These data demonstrate that dietary sodium intake influences renal tissue oxygenation, low sodium intake leading to an increased renal medullary oxygenation both in normotensive and young hypertensive subjects.
Sujets
PID Serval
serval:BIB_6B4E84BB5150
PMID
Open Access
Oui
Date de création
2010-05-06T13:28:04.824Z
Date de création dans IRIS
2025-05-21T04:32:44Z