Titre
Evolution of isochores in rodents.
Type
article
Institution
Externe
Périodique
Auteur(s)
Robinson, M.
Auteure/Auteur
Gautier, C.
Auteure/Auteur
Mouchiroud, D.
Auteure/Auteur
Liens vers les personnes
ISSN
0737-4038
Statut éditorial
Publié
Date de publication
1997
Volume
14
Numéro
8
Première page
823
Dernière page/numéro d’article
828
Langue
anglais
Résumé
The most deviant isochore pattern within mammals was found in rat and mouse; most other mammals possess a different kind of isochore organization called the "general pattern." However, isochore patterns remain largely unknown in rodents other than mouse and rat. To investigate the taxonomic distribution of isochore patterns in rodents, we sequenced the nuclear gene LCAT (lecithin:cholesterol acyltransferase) from 17 rodents species (bringing the total of LCAT sequences in rodent to 19) and compared their GC contents at third codon positions and in introns. We also analyzed an extensive sequence database from rodents other than rat and mouse. All murid LCAT sequences are much poorer in GC than all nonrodent LCAT sequences, and the hamster sequence database shows exactly the same isochore pattern as rat and mouse. Thus, all murids share the same special isochore pattern--GC homogenization. LCAT sequences are GC-poor in hystricomorphs too, but the guinea pig sequence database indicates that large changes in GC content occur without an overall modification of the isochore pattern. This novel mode of isochore evolution is called GC reordering. LCAT sequences also show that the evolution of isochores in sciurids and glirids is nonconservative in comparison with that in nonrodents. Thus, at least two novel patterns of isochore evolution were found. No rodent investigated to date shared the general mammalian pattern.
PID Serval
serval:BIB_8F06CD3DBACA
PMID
Date de création
2011-09-01T12:12:37.618Z
Date de création dans IRIS
2025-05-21T04:48:38Z