Titre
Enhanced renin secretion in adrenalectomized rats with glucocorticoid-induced hypertension
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Kasser, A.
Auteure/Auteur
Waeber, B.
Auteure/Auteur
Nussberger, J.
Auteure/Auteur
Burris, J.
Auteure/Auteur
Brunner, H. R.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1064-1963
Statut éditorial
Publié
Date de publication
1985
Volume
7
Numéro
11
Première page
1619
Dernière page/numéro d’article
28
Notes
Comparative Study
Journal Article
Research Support, Non-U.S. Gov't
Journal Article
Research Support, Non-U.S. Gov't
Résumé
The role of circulating epinephrine in the regulation of renin release was studied in unanesthetized rats with glucocorticoid-induced hypertension. Biadrenalectomized Wistar rats were made hypertensive with methylprednisolone (20 mg/kg s.c. weekly) for 2 weeks and supplemented with deoxycorticosterone pivalate (10 mg/kg s.c. weekly). Sham-operated controls received the same treatment. Baseline weight, mean intra-arterial blood pressure and heart rate of the groups were the same. In both adrenalectomized and sham-operated rats plasma renin activity was determined after a 30 min infusion of the beta-adrenoceptor stimulant isoproterenol (40 ng/min) or its vehicle. Isoproterenol had no blood pressure effect and accelerated heart rate to a similar extent in rats with and without adrenals. Plasma renin activity was significantly higher in epinephrine-deficient than in sham-operated rats. Renin secretion was significantly enhanced by isoproterenol in both groups of rats. These data therefore indicate that in rats with glucocorticoid-induced hypertension the renin-angiotensin system is activated by adrenalectomy, despite the fact that adrenal insufficiency cannot develop. It also appears that rats lacking of circulating epinephrine for a prolonged period do not exhibit an abnormal responsiveness of renin secretion to the stimulation of renal beta-adrenoceptors.
Sujets
PID Serval
serval:BIB_D0FDE67B27FC
PMID
Date de création
2008-03-05T15:39:45.333Z
Date de création dans IRIS
2025-05-21T04:59:03Z