Titre
A preclinical model for identifying rats at risk of alcohol use disorder.
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Jadhav, K.S.
Auteure/Auteur
Magistretti, P.J.
Auteure/Auteur
Halfon, O.
Auteure/Auteur
Augsburger, M.
Auteure/Auteur
Boutrel, B.
Auteure/Auteur
Liens vers les personnes
ISSN
2045-2322
Statut éditorial
Publié
Date de publication
2017-08-25
Volume
7
Numéro
1
Première page
9454
Peer-reviewed
Oui
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: epublish
Publication Status: epublish
Résumé
Alcohol use is one of the world's leading causes of death and disease, although only a small proportion of individuals develop persistent alcohol use disorder (AUD). The identification of vulnerable individuals prior to their chronic intoxication remains of highest importance. We propose here to adapt current methodologies for identifying rats at risk of losing control over alcohol intake by modeling diagnostic criteria for AUD: inability to abstain during a signaled period of reward unavailability, increased motivation assessed in a progressive effortful task and persistent alcohol intake despite aversive foot shocks. Factor analysis showed that these three addiction criteria loaded on one underlying construct indicating that they represent a latent construct of addiction trait. Further, not only vulnerable rats displayed higher ethanol consumption, and higher preference for ethanol over sweetened solutions, but they also exhibited pre-existing higher anxiety as compared to resilient rats. In conclusion, the present preclinical model confirms that development of an addiction trait not only requires prolonged exposure to alcohol, but also depends on endophenotype like anxiety that predispose a minority of individuals to lose control over alcohol consumption.
PID Serval
serval:BIB_F3999F21A3C1
PMID
Open Access
Oui
Date de création
2017-09-01T06:48:37.553Z
Date de création dans IRIS
2025-05-21T05:50:39Z
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Nom
s41598-017-09801-1.pdf
Version du manuscrit
published
Taille
1.24 MB
Format
Adobe PDF
PID Serval
serval:BIB_F3999F21A3C1.P001
URN
urn:nbn:ch:serval-BIB_F3999F21A3C11
Somme de contrôle
(MD5):c2c4152db40b5adeed1d87fe24d3d884