Titre
Changes in insulin secretion and glucose metabolism induced by dexamethasone in lean and obese females
Type
article
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Besse, C.
Auteure/Auteur
Nicod, N.
Auteure/Auteur
Tappy, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
1071-7323
Statut éditorial
Publié
Date de publication
2005-02
Volume
13
Numéro
2
Première page
306
Dernière page/numéro d’article
11
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Feb
Research Support, Non-U.S. Gov't --- Old month value: Feb
Résumé
OBJECTIVE: In healthy lean individuals, changes in insulin sensitivity occurring as a consequence of a 2-day dexamethasone administration are compensated for by changes in insulin secretion, allowing glucose homeostasis to be maintained. This study evaluated the changes in glucose metabolism and insulin secretion induced by short-term dexamethasone administration in obese women. RESEARCH METHODS AND PROCEDURES: Eleven obese women with normal glucose tolerance were studied on two occasions, without and after 2 days of low-dose dexamethasone administration. A two-step hyperglycemic clamp (7.5 and 10 mM glucose) with 6,6 (2)H(2) glucose was used to assess insulin secretion and whole body glucose metabolism. Results were compared with those obtained in a group of eight lean women. RESULTS: Without dexamethasone, obese women had higher plasma insulin concentrations in the fasting state, during the first phase of insulin secretion, and at the two hyperglycemic plateaus. However, they had normal whole body glucose metabolism compared with lean women, indicating adequate compensation. After dexamethasone, obese women had a 66% to 92% increase in plasma insulin concentrations but a 15.4% decrease in whole body glucose disposal. This contrasted with lean women, who had a 91% to 113% increase in plasma insulin concentrations, with no change in whole body glucose disposal. DISCUSSION: Dexamethasone administration led to a significant reduction in whole body glucose disposal at fixed glycemia in obese but not lean women. This indicates that obese women are unable to increase their insulin secretion appropriately.
Sujets
PID Serval
serval:BIB_F0ED55DE8070
PMID
Open Access
Oui
Date de création
2008-01-24T12:36:57.347Z
Date de création dans IRIS
2025-05-21T06:00:26Z