Titre
Pathologic fracture of the femur neck as first manifestation of a minute columnar cell carcinoma of the thyroid gland
Type
étude de cas
Institution
UNIL/CHUV/Unisanté + institutions partenaires
Périodique
Auteur(s)
Genton, C. Y.
Auteure/Auteur
Dutoit, M.
Auteure/Auteur
Portmann, L.
Auteure/Auteur
Gillet, M.
Auteure/Auteur
Guillou, L.
Auteure/Auteur
Liens vers les personnes
Liens vers les unités
ISSN
0344-0338
Statut éditorial
Publié
Date de publication
1998
Volume
194
Numéro
12
Première page
861
Dernière page/numéro d’article
3; discussion 865-6
Notes
Case Reports
Journal Article
Journal Article
Résumé
This case report concerns a 64 year-old woman who presented a pathologic fracture of the femur neck. Histologic examination of the performed bone biopsy disclosed the presence of a carcinomatous metastasis with unusual microscopic features. The site of the primary tumor could be unequivocally determined as being the thyroid gland, as immunostaining of the tumor cells showed positivity with anti-thyroglobulin. The thyroidectomy specimen weighed 149 g, was nodular and partially calcified. Exhaustive microscopic examination finally revealed the presence of a minute columnar cell carcinoma, 0.6 cm in diameter, with obvious vascular invasion. This case illustrates well 1) the usefulness of immunostaining with anti-thyroglobulin in cases of bone metastasis with unusual microscopic features and unknown primary, as well as 2) the aggressiveness of this rare type of carcinoma of the thyroid.
Sujets
PID Serval
serval:BIB_DF8FF725BAC7
PMID
Date de création
2008-01-28T11:14:20.303Z
Date de création dans IRIS
2025-05-21T06:32:15Z