Titre
Intrahepatic HCV RNA loads in 37 HIV-HCV co-infected patients with controlled HIV infection
Type
article
Institution
Externe
Périodique
Auteur(s)
Trimoulet, P.
Auteure/Auteur
Neau, D.
Auteure/Auteur
Le Bail, B.
Auteure/Auteur
Rullier, A.
Auteure/Auteur
Winnock, M.
Auteure/Auteur
Galperine, T.
Auteure/Auteur
Legrand, E.
Auteure/Auteur
Schvoerer, E.
Auteure/Auteur
Dupon, M.
Auteure/Auteur
Ragnaud, J. M.
Auteure/Auteur
Bioulac-Sage, P.
Auteure/Auteur
Chene, G.
Auteure/Auteur
Fleury, H.
Auteure/Auteur
Lafon, M. E.
Auteure/Auteur
Liens vers les personnes
ISSN
0146-6615
Statut éditorial
Publié
Date de publication
2002-06
Volume
67
Numéro
2
Première page
143
Dernière page/numéro d’article
51
Langue
anglais
Notes
Trimoulet, P
Neau, D
Le Bail, B
Rullier, A
Winnock, M
Galperine, T
Legrand, E
Schvoerer, E
Dupon, M
Ragnaud, J M
Bioulac-Sage, P
Chene, G
Fleury, H
Lafon, M E
eng
2002/05/07
J Med Virol. 2002 Jun;67(2):143-51. doi: 10.1002/jmv.2203.
Neau, D
Le Bail, B
Rullier, A
Winnock, M
Galperine, T
Legrand, E
Schvoerer, E
Dupon, M
Ragnaud, J M
Bioulac-Sage, P
Chene, G
Fleury, H
Lafon, M E
eng
2002/05/07
J Med Virol. 2002 Jun;67(2):143-51. doi: 10.1002/jmv.2203.
Résumé
Serum and intrahepatic hepatitis C virus (HCV) RNA were measured in 37 HIV-HCV co-infected patients with controlled human immunodeficiency virus (HIV) infection and correlated with clinical, biological, and histological parameters. Thirty-seven interferon-naive patients underwent liver biopsy. HCV-induced activity (A) and fibrosis (F) were evaluated with METAVIR score. The 37 patients included had HIV plasma loads < 10,000 copies/ml, CD4(+) count > 250/microl. All the patients but two were receiving antiretroviral treatment. Liver tissue and sera were used for measurement of HCV RNA by the Cobas Amplicor HCV Monitor. All patients had serum and liver HCV RNA, and both levels were correlated (r = 0.47; P = 0.003). Intrahepatic HCV load did not depend on age, sex, duration of HCV infection, CD4(+), HCV genotype, or fibrosis. AST levels correlated with intrahepatic HCV load (r = 0.52; P = 0.001). Patients with METAVIR A1/A2 had significantly lower levels of liver HCV-RNA than were found in patients with METAVIR A3 (P = 0.026). Highly active antiretroviral therapy (HAART) including protease inhibitors(PI)-treated patients had significantly lower intrahepatic HCV load (P = 0.04). A weak but significant correlation between serum and liver HCV RNA was found. The amount of hepatic HCV RNA was correlated with AST levels, histological activity, but not with HCV genotype or fibrosis. The immune improvement associated with PI regimens could help reduce HCV load, supporting a protective effect of PI-induced immune restoration.
PID Serval
serval:BIB_FD57F69C57EF
PMID
Date de création
2023-01-30T10:16:46.702Z
Date de création dans IRIS
2025-05-21T07:09:00Z