Titre
Fear of dying and inflammation following acute coronary syndrome
Type
article
Institution
Externe
Périodique
Auteur(s)
Steptoe, A.
Auteure/Auteur
Molloy, G. J.
Auteure/Auteur
Messerli-Burgy, N.
Auteure/Auteur
Wikman, A.
Auteure/Auteur
Randall, G.
Auteure/Auteur
Perkins-Porras, L.
Auteure/Auteur
Kaski, J. C.
Auteure/Auteur
Liens vers les personnes
ISSN
1522-9645
Statut éditorial
Publié
Date de publication
2011-10
Volume
32
Numéro
19
Première page
2405
Dernière page/numéro d’article
11
Langue
anglais
Notes
Steptoe, Andrew
Molloy, Gerard J
Messerli-Burgy, Nadine
Wikman, Anna
Randall, Gemma
Perkins-Porras, Linda
Kaski, Juan Carlos
eng
RG/10/005/28296/British Heart Foundation/United Kingdom
MRC_/Medical Research Council/United Kingdom
Research Support, Non-U.S. Gov't
England
Eur Heart J. 2011 Oct;32(19):2405-11. doi: 10.1093/eurheartj/ehr132. Epub 2011 Jun 1.
Molloy, Gerard J
Messerli-Burgy, Nadine
Wikman, Anna
Randall, Gemma
Perkins-Porras, Linda
Kaski, Juan Carlos
eng
RG/10/005/28296/British Heart Foundation/United Kingdom
MRC_/Medical Research Council/United Kingdom
Research Support, Non-U.S. Gov't
England
Eur Heart J. 2011 Oct;32(19):2405-11. doi: 10.1093/eurheartj/ehr132. Epub 2011 Jun 1.
Résumé
AIMS: Many patients are afraid of dying during acute coronary syndrome (ACS), but the origins and biological correlates of these emotional responses are poorly understood. This study evaluated the prevalence of fear of dying, associations with inflammatory responses during ACS, and later heart rate variability (HRV) and cortisol secretion. METHODS AND RESULTS: Two hundred and eight patients admitted with clinically verified ACS rated their fear of dying on interview in hospital. Plasma tumour necrosis factor (TNF)alpha was recorded on admission, and HRV and salivary cortisol were assessed 3 weeks later. Intense distress and fear of dying was experienced by 21.7%, with moderate levels in 66.1% patients. Fear of dying was more common in younger, lower socioeconomic status, and unmarried patients. It was positively associated with plasma TNFalpha on admission after controlling for sociodemographic factors, clinical risk, and pain intensity (adjusted odds = 4.67, 95% C.I. 1.66-12.65). TNFalpha was associated with reduced HRV 3 weeks later, adjusting for clinical and sociodemographic factors and medication (P = 0.019), while fear of dying was associated with reduced cortisol output (P = 0.004). CONCLUSIONS: Intense distress and fear of dying and heightened inflammation may be related manifestations of an acute biobehavioural response to severe cardiac injury, and have implications for prognostically significant biological risk processes.
PID Serval
serval:BIB_0099A084AF63
PMID
Date de création
2021-11-08T17:13:43.705Z
Date de création dans IRIS
2025-05-20T13:20:01Z